Scientists for the first time synthesized a natural anticancer substance halichondrin


The synthetic analogue of halichondrin, which is a powerful natural anticancer substance, was first developed by Japanese and American scientists.

Galichondrin, a very strong natural antioxidant, was discovered in sea sponges 33 years ago, and since then, scientists have repeatedly tried to reproduce this substance in the laboratory in the form of a medicinal formula. But only now the international team of specialists was finally able to synthesize the long-awaited medicine. This is reported on the website of Harvard University.

Galichondrin has the property of destroying the components of the microenvironment of the tumor, due to which the conversion of healthy cells into malignant ones takes place. It is known that under its influence the formation of structures that are involved in the division of cancer cells stops.

Prior to this, in 1992, scientists developed a simplified version of halichondrin, which was distantly similar in composition to halichondrin B. This substance is still used to treat metastatic breast cancer and liposarcoma. This time, according to the authors of the study, they “managed to get 11.5 grams of a substance with a purity of 99.81% – this should be enough to conduct a clinical study of the drug in humans.

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The molecule they developed, called E7130B, was tested in in vitro (in vitro) and in vivo experiments (animal models). These tests have shown that scientifically synthesized halichondrin can increase intratumoral CD31-positive endothelial cells and reduce Alpha-SMA-positive cancer-related fibroblasts — components surrounded by a tumor that can help with its malignant transformation, if necessary.

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